Objective: The aim of this study was to determine an effective treatment by antibiotic for positive culture (culture+ve) pyogenic spondylodiscitis compared to a negative culture (culture-ve) by assessment of laboratory outcomes, Erythrocyte Sedimentation Rate (ESR) and C-reactive protein (CRP). The secondary objective is to determine incidence of pathogen micro-organisms of pyogenic spondylodiscitis.
Material and Method: The study design was a single-center retrospective study performed by the ICD10 computer database of the Department of Orthopedic Surgery in the Prince of Songkla University for patient diagnosed pyogenic spondylodiscitis. After exclusion was done, patients were divided into 2 groups of study. The first group was tissue ulture+ve while the second group was tissue culture-ve. Patient culture+ve were analyzed for bacterial pathogen  along with antibiotic sensitivity. In culture-ve patients were analyzed for the types of antibiotic and its usage. Both of two groups was compared with the effectiveness of treatment with ESR and CRP beforehand, and after four-weeks of treatment.
Results: Compared with 56 culture+ve patients, the 69 culture-ve patients were no significant difference in median difference of ESR and CRP at the time before treatment and at four-weeks, after treatment.
Conclusion: Antibiotic treatment of non-identified micro-organism pyogenic spondylodiscitis can be done by using the most common incidence of micro-organism. The effectiveness of antibiotic treatment was determine by ESR and CRP beforehand, and after four-weeks of antibiotic treatment.