Tuberculosis (TB) can infect any part of the body. Preauricular sinus is a congenital anomaly of the external ear. Infection of the preauricularsinus is mainly caused by bacteria. This is a case report of TB of preauricular abscess which presented with an unresponsive abscess to an antibiotic. TB of preauricular abscess is extremely rare, and assumed to have the same etiology as cutaneous tuberculosis. Treatments are standard anti-TB drugs with excision of preauricular sinus. This case emphasizes the consideration of TB in a preauricular abscess that does not respond toantibiotics, incision and drainage.