Objective: To report the long-term outcomes of patients with mechanical valve replacement in terms of valve related complications and death.

Material and Method: The medical records of 260 patients who underwent mechanical valve replacement between January 2001 to December 2012 were retrospectively reviewed. Late valve related complications and death rates were calculated with Kaplan-Meier analysis. The status of the patients who were lost during follow up was retrieved from Registration Database of Department of Provincial Administration.

Results: During follow up time, 63 patients (26.9%) developed valve related complications. Of these, 40 patients died. The valve-specific complication-free survival rates at 5 and 10 years were 75.4% and 69.2% respectively. The valve-specific survival rates at 5 and 10 years were 85.8% and 80.5% respectively.

Conclusion: The long-term outcomes of patients with mechanical valve replacement in this study was comparable to other studies. The data from this study could be a reference for further study in the management of patients with prosthetic heart valve.