Paraneoplastic syndrome (PNS) is found in parallel with some cancers, including small cell lung cancer (SCLC). Neoplastic cells can produce a variety of peptides that exert biological actions at both local and distant sites. Symptoms and signs associated with paraneoplastic disorders may be overlookedin diagnosis and management.

In this article we review the endocrinological changes, well characterized paraneoplastic antibodies and classical neurological syndromes associated with small cell lung cancer.