Staphylococcus aureus is one of the major causes of nosocomial infections, pyoarthritis, endocarditis and other disorders. Additionally, the presence of antibiotic-resistant S. aureus especially for methicillin resistant S. aureus (MRSA) is of great concern in medical treatment. This present paper aims to provide fundamental and detailed information of MRSA including morphology, strain distribution, antibiotic-resistant mechanism and means to control MRSA. The potential use of natural products will also be discussed.