Introduction: At present there are many alternative treatments for closure of patent ductus arteriosus (PDA). The preferred technique should be safe and effective in terms of morbidity, mortality, cost, and length of hospital stay. 
 Objective: To assess the surgical treatment outcome of patent ductus arteriosus by combined ligation and clipping technique.
Materials and methods: From December 2001 to October 2010, 112 patients with isolated PDA were treated by this technique. Through left mini-thoracotomy, the ductus was simple double ligated with heavy silk and also clipped with one titanium clip. Usually, the patients could be discharged home within one or two days of the operation.
Results: There was no death or serious post-operative complication. There was no residual shunt on follow up.
Conclusions: Combined ligation and clipping was safe and effective for treatment of PDA, especially in infants and children.