Durian contains high carbohydrates and high fats. Thus, many people believe that patients with diabetes or patients with hypercholesterolemia should avoid consumption of durian. The objective of this article is to review nutrition facts and pharmacology of durian. Although, there is a clinical trial in humans showed that the glycemic index of durian is relatively low (49±5%), there is not enough evidence to support pharmacology of durian in humans. Several animal experiments have shown that diets supplemented with durian significantly hindered the rise in plasma lipid. Many in-vitro and in-vivo studies confirmed the antioxidant activity of durian. However, no study has been conducted to investigate antioxidant activity of durian in humans. An in-vitro study demonstrated antiproliferative activity of durian in carcinoma cells. Based on the fact that durian inhibits aldehyde dehydrogenase enzyme, coadministration of durian and alcohol should be done with caution. In summary, there is not enough evidence to support that durian consumption might be beneficial to health. Due to, most experiments were in-vitro and conducted in animals.