“Handoff” is a significant tool used by healthcare providers to ensure continuous and safe care. However, adverse consequences resulting from handoff breakdowns are common. This article reviewed in-hospital handoff studies, published in the English language from 2005 to 2011, to identify handoff improvement interventions and their outcomes. The results revealed that various handoff improvement interventions were undertaken and examined. These included person-to-person handoff, bedside handoff, supplementing the current handoff with other information sources, information templates/checklists/sheets/forms, handoff protocols, computerized handoff systems, and voicemail handoff. Other interventions were handoff education/training/programs, the reflexivity method, and a combination of different handoff methods. The impact of these interventions was assessed mainly in four targets: systems; information; healthcare providers; and patients. Only a few studies reviewed directly evaluated the impact of the interventions on patients. Of these, implementing a computerized handoff system and using information tools appeared to promote continuity of patient care. Moreover, very few studies rigorously evaluated the impact of handoff improvement interventions on patients. Since handoff is ultimately intended to benefit the patient, rigorous studies should be undertaken to identify the best handoff method associated with satisfactory outcomes for patients.